Effect of Trasylol on Expression of CD4~+ and CD8~+ T Lymphocytes in Brain Tissue of Cerebral Ischemia- reperfusion Rats
- VernacularTitle:抑肽酶对脑缺血再灌注大鼠脑组织CD4~+、CD8~+T淋巴细胞表达的影响
- Author:
Chengping JIANG
;
Xiaoming WANG
;
Bihua WU
;
Fu LIU
- Publication Type:Journal Article
- Keywords:
Trasylol;
Cerebral ischemia-reperfusion injury;
CD4+ T lymphocytes;
CD8+ T lymphocytes;
Rats
- From:
China Pharmacy
2005;0(21):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To study protection effect of trasylol on cerebral injury resulting from cerebral ischemia-reperfusion in the interference of immunological response.METHODS: 105 SD rats were randomly assigned into sham operation group,model group and trasylol group (n=35).Focal ischemia-reperfusion model were established by occluding middle cerebral artery.24 h before ischemia and at the 0 h,24 h,4 d,6 d,8 d,10 d,12 d and 14 d of reperfusion,trasylol group were given trasylol via tail vein and other two groups were given normal saline.The infiltration of CD4+ and CD8+ T lymphocytes was observed using immunohistochemistry at different stages of cerebral ischemia-reperfusion.RESULTS: As compared with sham operation group,CD4+and CD8+ T lymphocytes count in model group were increased significantly after cerebral ischemia-reperfusion injury and obtained maximum value at 10th day.CD4+ and CD8+ T lymphocytes count in trasylol group were lower than in model group after cerebral ischemia-reperfusion injury and obtained maximum value at 8th day (P
