Effects of Ketamine on Pharmacokinetics and Pharmacodynamics of Propofol
- VernacularTitle:氯胺酮对丙泊酚药动学与药效学的影响研究
- Author:
Shuangju ZHANG
- Publication Type:Journal Article
- Keywords:
Propofol;
Ketamine;
Pharmacokinetics;
Pharmacodynamics
- From:
China Pharmacy
2005;0(22):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the effects of ketamine on pharmacokinetics and pharmacodynamics of propofol. METHODS:24 outpatients undergoing painless abortion were randomly assigned into group A(2.5 mg?kg-1propofol via i.v.,n=8), group B(propofol combined with 0.25 mg?kg-1 ketamine,n=8)and groups C(propofol combined with 0.75 mg?kg-1 ketamine, n=8). Blood samples were taken from basilical vein or brachial veins at 0 min,2 min,4 min,6 min,8 min,10 min,15 min, 30 min,45 min,1 h,2 h,3 h after medication,and at wake-up time and sober moments. Plasma concentrations of propofol were measured by HPLC and pharmacokinetic parameters were calculated using 3p97 software. SBP,DBP,HR and SpO2 were detected. RESULTS:Compared with group A,t1/2? and Vd in group B and group C decreased(group A vs. group C,P
