Experimental Study on the Effects of Potassium Fructose Diphosphate on Ischemia-reperfusion Induced Arrhythmia
- VernacularTitle:果糖二磷酸钾盐抗缺血再灌注心律失常作用的实验研究
- Author:
Hui YANG
- Publication Type:Journal Article
- Keywords:
Potassium fructose diphosphate;
Arrhythmias;
Ischemia-reperfusion;
Rats;
Rabbit
- From:
China Pharmacy
2005;0(21):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To investigate the effect of potassium fructose diphosphate (FDPK) on ischemia-reperfusion induced by arrhythmia and its mechanism.METHODS: 60 rats were randomized into model group,FDPK high-dose group (80 mg?kg-1),FDPK medium-dose group (40 mg?kg-1),FDPK low-dose group (20 mg?kg-1),FDP group and potassium chloride (KCl) group.Ischemia-reperfusion induced by arrhythmia model was induced by occlusion and reirregation.The score of arrhythmia,the level of MDA,the activity of SOD and ATPnase of those groups were investigated.Hypokalemia rabbit model was induced and treated with normal saline,KCl,magnesium aspartate and FDPK.The concentrations of potassium ion in lymphocyte were also detected.RESULTS: As compared with model group,FDPK could decrease the score of arrhythmia,the level of MDA but increase the activity of SOD and ATPnase (P
