Study on Relationship of Oil/water Partition Coefficient with Nasal Absorption Constant of Fluorouracil
- VernacularTitle:氟尿嘧啶的脂水分配系数与鼻腔吸收速率常数的相关性研究
- Author:
Aiping ZHENG
- Publication Type:Journal Article
- Keywords:
5-fluorouracil;
Octanol-water;
Oil/water partition coefficient;
Nasal absorption constant
- From:
China Pharmacy
2005;0(21):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To study the relationship of oil/water partition coefficient of fluorouracil (5-FU) with its nasal absorption.METHODS: The octanol /water partition coefficient of 5-FU in Octanol-water were determine at different pH condition (4,6,7,8,10).In situ nasal recirculation method was used to estimate nasal absorption constant of 5-FU at different pH condition in rat.Regression analysis of obtained data was carried out.RESULTS: Oil/water partition coefficient and nasal absorption constant of 5-FU were increased as long as the value of pH with a positive correlation between them (r=0.983 8).CONCLUSION: There is a good linear relationship between oil/water partition coefficient and nasal absorption constant.
