Study on Co-grinding Method Improving the Dissolution Rate of Nitrendipine in Vitro
- VernacularTitle:共研磨法改善尼群地平体外溶出度的研究
- Author:
Bengang YOU
;
Haimin PAN
;
Lihua TANG
;
Wenfeng ZHOU
;
Xiaoli ZHAO
;
Weihua WU
- Publication Type:Journal Article
- Keywords:
Nitrendipine;
Co-grinding method;
In vitro dissolution;
Powder;
Tablet;
Single-factor test
- From:
China Pharmacy
2005;0(21):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To improve the dissolution rate of nitrendipine in vitro using co-grinding method.METHODS: Single-factor test was adopted to detect effect of phases of co-grinding,category of excipients (MCC,PVPk30,HPC,HPMC),time (0,10,20,30,40,50,60 min) of co-grinding and ratio of principal component to excipients (1 ∶ 1,1 ∶ 2,1 ∶ 3,1 ∶ 4,1 ∶ 5,1 ∶ 6,1 ∶ 7,1 ∶ 8,1 ∶ 9) on in vitro dissolution of nitrendipine power and tablet.RESULTS: The condition of co-grinding method was as follows: dual co-grinding phase,HPC or MCC as excipients,co-grinding time of 40 min,ratio of principal component to excipients was 1 ∶ 4.Accumulative dissolution rate of nitrendipine powder was more than 80% within 10 min and that of nitrendipine tablet was more than 80% within 40 min.CONCLUSION: Co-grinding method can improve the dissolution rate of poorly water-soluble nitrendipine in vitro under suitable condition.
