Preparation and Quality Control of Doxycycline Hydrochloride Microspheres
- VernacularTitle:盐酸多西环素微球的制备及质量控制
- Author:
Aiping DENG
;
Yi WANG
- Publication Type:Journal Article
- Keywords:
Doxycycline hydrochloride;
Microspheres;
Poly (lactic-co-glycolic acid);
Preparation;
Quality;
Drug release in vitro
- From:
China Pharmacy
2005;0(21):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To prepare doxycycline hydrochloride microspheres and to establish a method for its quality control.METHODS: O/O emulsion solvent evaporation method was adopted to prepare doxycycline hydrochloride microspheres with poly (lactic-co-glycolic acid) (PLGA) as carrier.Light microscope was used to detect appearance and particle size of microspheres and UV spectrophotometry was applied to determine the loading rate and release rate of drug in vitro.RESULTS: Prepared microspheres are smooth and round with mean particle size of (49?6.9) ?m and span of 0.9.Average drug loading rate was (3.3?0.2) % and encapsulation efficiency was (52.4?3.2) % (n=3).Accumulative drug release reached 28% within 0.5 h with constant drug release lasting more than 30 days.CONCLUSION: Doxycycline hydrochloride microspheres preparation process is available and controllable in quality.
