Preparation of Injectable Thermosensitive Meloxicam Hydrogel
- VernacularTitle:可注射美洛昔康温敏凝胶的研制
- Author:
Minyan CHEN
;
Feihua WU
;
Jiuying PAN
;
Zhigui JIN
- Publication Type:Journal Article
- Keywords:
Thermosensitive meloxicam hydrogel;
Chitosan-glycerin-borax;
Temperature;
pH;
In vitro release
- From:
China Pharmacy
2005;0(21):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To develop a new type of injectable sustained thermosensitive meloxicam hydrogel.METHODS: Injectable thermosensitive meloxicam hydrogel was prepared with chitosan-glycerin-borax as carrier.The influence factors of hydrogel were studied such as preparation temperature,pH value,the ratio of glycerin to chitosan.In vitro release of samples was also evaluated.RESULTS: Optimal preparation condition was as follows: preparation temperature was 37 ℃ with pH value of 7.0 and the ratio of glycerin to chitosan was 3 ∶ 10.Mean accumulative release of samples was 76% within 288 h.CONCLUSION: Established method is simple and preparation is characterized with high temperature sensitivity and sustained-release.
