Clinical Value of Hepatitis Screening and Liver Function Test in Korean Patients with Lichen Planus.
- Author:
Min Gun YOO
1
;
Jae Beom PARK
;
Hee Won JANG
;
Sang Geun LEE
;
Sang Wook SON
;
Il Hwan KIM
Author Information
1. Department of Dermatology, Korea University College of Medicine, Seoul, Korea. kumcihk@korea.ac.kr
- Publication Type:Multicenter Study ; Original Article
- Keywords:
Hepatitis;
Korean;
Lichen planus;
Liver function
- MeSH:
Alanine Transaminase;
Aspartate Aminotransferases;
Hepacivirus;
Hepatitis B Surface Antigens;
Hepatitis B virus;
Hepatitis*;
Humans;
Lichen Planus*;
Lichens*;
Liver Diseases;
Liver Function Tests*;
Liver*;
Mass Screening*;
Prevalence;
Retrospective Studies
- From:Korean Journal of Dermatology
2013;51(12):956-959
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The relationship between viral hepatitis and lichen planus (LP) remains as a matter of controversy. Geographical variations are suggested to be a major factor influencing such association. Reliable figures from Korean patients are still lacking. OBJECTIVE: The aim of this study is to determine the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections in Korean patients with lichen planus (LP) and to compare it with patients without LP. METHODS: The retrospective study was performed on 45 LP patients and 45 controls with matching age and gender. We examined for serological evidences of hepatic disease, hepatitis B surface antigen (HBsAg), and anti-HCV seropositivity. Statistical analysis was calculated by using an unpaired t-test and Fisher's exact test. RESULTS: No significant differences between the serum levels of alanine aminotransferase (ALT), and aspartate aminotransferase (AST) were observed between the two groups. The prevalence of HBsAg in LP patients (4.4%) was not significantly higher (p>0.05) than those of the control subjects (2.2%). None of the patients with LP nor the control subjects had Anti-HCV. CONCLUSION: Korean patients with LP did not have any significant associations with liver diseases or HBV, and HCV infections. Although a large-scale multicenter study is needed to support our results, it is not advisable for Korean patients with LP to be tested for liver functions or HBV, and HCV infections as part of a routine screening test.
