Study on Individual Norvancomycin Chain Bead Regimen in the Treatment of Methicillin-resistance Staphylococcus Infection Chronic Osteomyelitis
- VernacularTitle:去甲万古霉素链珠个体化治疗耐甲氧西林葡萄球菌感染的慢性骨髓炎的研究
- Author:
Xiaojun PANG
;
Cuiye HUANG
;
Maode LU
;
Guangtian YI
- Publication Type:Journal Article
- Keywords:
Methicillin-resistance staphylococcus;
Chronic osteomyelitis;
Bone cement;
Norvancomycin;
Clinical pharmacist
- From:
China Pharmacy
2005;0(20):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore new therapy regimen for methicillin-resistance staphylococcus infection chronic osteomyelitis. METHODS:27 patients with methicillin-resistance staphylococcus infection chronic osteomyelitis were randomly divides into 2 groups. Both groups were injected with norvancomycin intravenously before operation to prevent infection. Norvancomycin chain bead (NCB) which were made from norvancomycin and bone cement was used to make up bone defect in NCB group(15 patients). Bone cement was used to make up bone defect in norvancomycin group(12 patients). The cure rates, the cost of infection therapy, the incidence of ADR and therapy duration were compared between 2 groups. RESULTS: Both NCB and intravenous administration of norvancomycin had sound effect on chronic osteomyelitis. The incidence of ADR and the cost of infection therapy of NCB regimen were close to low level. The infection was controlled effectively. CONCLUSION:Individual NCB regimen is superior to intravenous administration of norvancomycin in the treatment of methicillin-resistance staphylococcus infection chronic osteomyelitis.
