Effect of Erdong Granules on Glucose Metabolism and Lipid Metabolism in Type 2 Diabetes Mellitus Rats
- VernacularTitle:二冬颗粒对2型糖尿病模型大鼠糖代谢和脂代谢的影响
- Author:
Hongxia CUI
;
Xianchun WEN
;
Juan SONG
;
Shu MIAO
- Publication Type:Journal Article
- Keywords:
Type2 diabetes mellitus;
Erdong granules;
Glucose metabolism;
Lipid metabolism;
Rats
- From:
China Pharmacy
2005;0(19):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the effect of Erdong granules on glucose metabolism and lipid metabolism in type 2 diabetes mellitus rats.METHODS:Type 2 diabetes mellitus model was induced by giving high-fat and high-calorie diet with intraperitoneal administration of streptozotcin for eight weeks.Model rats were divided into normal group,model group,streptozotcin group and erdong granules high-dose,middle-dose and low-dose groups.The levels of FBG,LDL-C,FFA,SOD and MDA were detected and immunohistochemistry method was used to determine the morphology change of islet cell.RESULTS:The serum levels of FBS,MDA,FFA and LDL-C in Erdong granules high-dose and low-dose group were significantly decreased while the activity of SOD was increased.Erdong granules could protect islet cell.CONCLUSION:Erdong granules can notably improve glucose metabolism and lipid metabolism,antioxidant enzyme activity and inhibit oxidative stress so as to protect islet cells of type 2 diabetic mellitus rats.
