Effect of Ginsenoside Rg_1 on Facial Nerve Regeneration in Ovariectomized Rats
- VernacularTitle:人参皂苷Rg_1对去卵巢大鼠面神经损伤修复的作用研究
- Author:
Cuiying ZHOU
;
Wenlong LUO
- Publication Type:Journal Article
- Keywords:
Ginsenoside Rg1;
Facial nerve injury;
Repair;
BDNF protein
- From:
China Pharmacy
2005;0(19):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the effect of ginsenoside Rg1 on facial nerve regeneration in ovariectomized rats.METHODS:48 ovariectomized SD rats were randomly assigned into sham operation group (normal saline),model group (normal saline),nerve growth factor group (NGF,10 mg?kg-1) and ginsenoside group (10 mg?kg-1).Ovariectomized model were induced and received relevant drugs.The behavior changes of rats were observed.The morphology changes of facial nucleus were detected under transmission electron microscope (TEM) and light microscopy.BDNF expression of facial nucleus was determined with immunohistochemistry.RESULTS:The morphology of the facial nucleus was improved.The BDNF expression of 3D facial nucleus in model group,NGF group and ginsenoside group were increased after facial nerve was injured.The BDNF expression was decreased on 7th day while increased on 14th day.The thickness of regenerating nerve fiber in ginsenoside group was superior to in model group (P
