Content Determination of Residual Organic Solvents in Artesunate by Capillary GC
- VernacularTitle:毛细管GC法测定青蒿琥酯中有机溶剂的残留量
- Author:
Hongying SUN
;
Aili ZHAO
;
Zhenguang LIN
- Publication Type:Journal Article
- Keywords:
Artesunate;
Organic solvents;
Residual;
Capillary GC;
Methanol;
Ethyl acetate
- From:
China Pharmacy
2005;0(19):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish capillary GC method for the determination of residual organic solvents in artesunate,such as methanol and ethyl acetate.METHODS:Capillary GC was adopted and the temperature of flame ionization detector was 250℃.RESULTS:The linear range were 0.03～0.605 mg?mL-1 for methanol(r=0.999 8) and 0.05～1.002 mg?mL-1 for ethyl acetate(r=0.999 7).The average recovery rates were 98.7% for methanol(RSD=3.0%) and 99.1% for ethyl acetate(RSD=2.1%).Only the ethyl acetate was detected in samples.CONCLUSION:Established method is simple and accurate for the content determination of residual organic solvents in artesunate.
