Analysis on the Correlated Factors of Methylene Tetrahydrofolate Reductase C676T Mutation and the Different TCM Syndromes in Early Diabetic Nephropathy
- VernacularTitle:早期糖尿病肾病患者亚甲基四氢叶酸还原酶C676T突变的相关因素及中医证型分析
- Author:
Lan LIN
;
Xiaozhou GUO
;
Qing NI
;
Yanbing GONG
;
Bin WANG
;
Shihua SHI
- Publication Type:Journal Article
- Keywords:
Diabetic nephropathy;
TCM syndrome;
Methylene tetrahydrofolate reductase(MTHFR);
Homocysteine(Hcy)
- From:
Journal of Traditional Chinese Medicine
1993;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between gene mutation and different syndromes of TCM in the early stage of diabetic nephropathy(DN).Methods Sixty-three patients with diabetic nephropathy in the early stage were observed.The methylene tetrahydrofolate reductase(MTHFR)C676T polymorphism was determined by polymerase chain reaction restriction fragment length polymorphism(PCR-RFLP)assay.The levels of homocysteine(Hcy),acidum folicum,fasting glucose,postprandial glucose,glycosylated hemoglobin(HbA1C),urinary albumin excretion rate(UAER),and blood lipid were measured respectively,and the TCM syndromes were recorded.Results Of the 63 patients,19 were genotype CC,17 were genotype TT,and 27 were genotype CT.The genotypic frequency of TT was 27.00%,that of CT was 42.85%,and that of CC was 30.15%.The T allele frequency was 48.41% and C allele frequency 51.59%.The MTHFR C676T mutation was related with plasma Hcy level(P
