Research progress in FTO gene and obesity
- VernacularTitle:FTO基因与肥胖关系的研究进展
- Author:
Zhihua XIAO
;
Wuhua GUO
;
Jixiang ZHANG
- Publication Type:Journal Article
- Keywords:
Gene,FTO;
Single-nucleotide polymorphism;
Obesity
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Obesity is a rapidly growing international health problem. The association of fat mass and obesity associated(FTO) gene and obesity is becoming the hot topic in the gene research. FTO is a member of the nonheme dioxygenase [Fe(Ⅱ) and 2-oxoglutarate-dependent dioxygenases]superfamily. FTO levels in the brain,especially in the hypothalamus,participate in the central control of food intake. The mutation of FTO gene accentuates body mass index,hip circumference and total weight,leading to obesity.
