Signal transduction pathways involved in the pathogenesis of autosomal dominant polycystic kidney disease
- VernacularTitle:常染色体显性遗传多囊肾病发病相关信号转导通路的研究进展
- Author:
Li ZHOU
;
Hong ZHOU
;
Baoxue YANG
- Publication Type:Journal Article
- Keywords:
Polycystic kidney,autosomal dominant;
Signal transduction
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Autosomal dominant polycystic kidney diseases are a large family of inherited diseases,which are characterized by the development of multiple renal cysts of tubular epithelial cell origin. Progressively enlarging cysts compromise normal renal parenchyma,reduce renal function and lead to renal failure. This review article summarizes recent literatures on the intracellular calcium homeostasis and signaling involving cAMP,EGFR and Ras/ERK,Wnt,m-TOR,as well as JAK-STAT,in the pathogenesis of polycystic kidney disease.
