rhBMP2 enhances migration and invasion capacity of human breast cancer cells MCF-7
- VernacularTitle:重组人骨形成蛋白-2提高人乳腺癌细胞MCF-7的迁移性
- Author:
Peide HUANG
;
Feicheng HUANG
;
Yang CHEN
;
Gang XIAO
;
Zhiyou ZHOU
;
Ju WANG
;
Tianhong ZHOU
- Publication Type:Journal Article
- Keywords:
Bone morphogenetic proteins-2;
MCF-7 cells;
Cell movement
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To determine the effect of rhBMP2 on the migration of human breast cancer cells MCF-7. METHODS:MCF-7 was induced by rhBMP2 (30 ?g/L) for 24 h. Atomic force microscopy (AFM) was used to observe the changes in cell morphology. Cell migration and invasion abilities were assayed by scratch healing and transwell experiments. RESULTS:The formation of lamellipodia and cell polarity together with increased cell length were observed in the cells treated with rhBMP2,whereas lamellipodia of cells in control group were not obvious and the majority of cells tended to be rounder with shorter cell diameter. Compared to control group,scratch healing and transwell experiments showed that the migration and invasion capacity of rhBMP2-induced MCF-7 cells was markedly enhanced. CONCLUSION:rhBMP2 induces human breast cancer cell MCF-7 to present the phenotype of migration and enhances the invasion capacity.
