Rat Model of Otitis Media with Effusion
- VernacularTitle:颌下径路阻塞咽鼓管创建大鼠分泌性中耳炎模型
- Author:
Zhenhua QIAO
;
Yanhong DAI
;
Lin XU
;
Wandong SHE
- Publication Type:Journal Article
- Keywords:
Otitis media with effusion(OME);
SD rats;
Animal model;
Eustachian tube
- From:
Journal of Audiology and Speech Pathology
1998;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish an otitis media with effusion model in rat,and provide a pure physical approach of animal model for researching the otitis media with effusion.Methods Twenty-four clean grade male SD rats were selected.Only the right ears were used for the model group,the contralateral ears were used as the control group.The animal model of otitis media with effusion was established by blocking eustachian tube with cork stopper through the right side mandible,the hearing was evaluated by ABR and tympanogram configurations,the pathologic changes of middle ear and eustachian tube mucous membrane were examined by light microscopy.Results Twenty out of 24 ears of rats' of hearing threshold increased from 34.25?5.45 dB to 57.63?5.46 dB (P
