Literature Analysis on ADR Induced by Quinolones in the Elderly
- VernacularTitle:喹诺酮类药致老年人不良反应文献分析
- Author:
Ming FAN
- Publication Type:Journal Article
- Keywords:
Quinolones;
ADR;
Elderly;
Literature analysis
- From:
China Pharmacy
2005;0(18):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To explore the status quo of ADR induced by quinolones in the elderly. METHODS: Retrieved from CNKI database with "quinolones" or "oxacin" as key words, 137 literatures about 173 ADR cases induced by quinolones in the elderly were statistically analyzed in respects of category of drugs, patients’ age and sex, route of administration, primary disease, occurrence time of ADR, organs and systems involved in ADR and clinical manifestation, etc. RESULTS: 12 kinds of quinolones were involved in ADR cases. 63.01% cases were male and 30.06% cases were the elderly (aged from 60 to 65). Main ADR manifested nervous reaction (33.53%), allergic reaction (20.81%) and pathoglycemia (17.34%). The main clinical manifestations of ADR in the nervous system were abnormal mental status and epilepsy (75.86%). Two cases were dead. CONCLUSION: Great importance should be attached to the ADR induced by quinolones in the elderly and occurrence of severe ADR (anaphylactic shock).
