Importance of Knowledge about Cytochrome P_(450) for Clinical Practice of Pharmaceutical Care
- VernacularTitle:应用细胞色素P_(450)知识对临床药学监护实践的重要性探讨
- Author:
Wanwei LUO
- Publication Type:Journal Article
- Keywords:
Cytochrome P450;
Pharmaceutical care;
Practice
- From:
China Pharmacy
2005;0(18):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To discuss the effect of cytochrome P450(CYP) on drug interaction. METHODS: Drug use in 30 clinical cases were summarized and analyzed retrospectively using knowledge concerning about CYP. RESULTS: Two types of CYP were involved. 29 cases of CYP3A4 accounted for 82.9% and 6 cases of CYP1A2 accounted for 17.1%. 31 cases of drug interaction induced by inhibition effect of enzyme accounted for 68.9% and 14 cases of drug interaction induced by induction effect of enzyme accounted for 31.1%. CONCLUSION: Clinical pharmacist should master more knowledge concerning about CYP and remind physicians pay attention to potential drug interaction associated with CYP in order to avoid adverse drug reaction and reduce the drug-induced disease.
