Investigation on the Effect and Mechanisms of Tea Polyphenols on Lung Injury Caused by Global Cerebral Ischemic-reperfusion
- VernacularTitle:茶多酚抗全脑缺血再灌注继发肺损伤的作用及机制研究
- Author:
Xiaoli SONG
- Publication Type:Journal Article
- Keywords:
Tea polyphenyl;
Rats;
Global cerebral ischemic-reperfusion;
Lung injury;
SOD;
MDA;
CD14
- From:
China Pharmacy
2005;0(17):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To investigate the protective effects of tea polyphenol (TP) on lung injury caused by global cerebral ischemic-reperfusion and its mechanism. METHODS: Improved Pulsinelli-brierley method was applied to induce damage model by global cerebral ischemia model for 15 min and global cerebral ischemia-perfusion for 3 h. Some indexes were observed, including morphology change of cerebral and lung tissue, activity of superoxide dismutase (SOD), concentration of malondialdehyde (MDA) and expression of lipopolysaccharide receptor CD14. Healthy rats were divided into sham group, model group and nimodipine group. RESULTS: As compared with sham group, there were pathologic damage of lung and brain and the positive expression of CD14 cell of lung in model group. As compared with model group, the activity of SOD were increased significantly (P
