Clinical Efficacy of Granisetron Combined with Lidocaine Pretreatment in Minimizing Propofol Injection Pain and Vomiting
- VernacularTitle:格拉司琼复合利多卡因静脉预处理减轻异丙酚所致注射痛和呕吐的临床观察
- Author:
Haiqing FU
- Publication Type:Journal Article
- Keywords:
Granisetron;
Lidocaine;
Propofol;
Injection pain
- From:
China Pharmacy
2005;0(16):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe clinical efficacy of specific 5-HT receptor antagonist granisetron combined with intravenous local anesthetic lidocaine pretreatment in minimizing propofol injection pain. METHODS:400 selective patients with laparoscopic cholecystectomy randomized into control group(group A),lidocaine group(group B),granisetron group(group C)and lidocaine combined with granisetron group(group D),n=100. Group A were treated with 3 mL normal saline and group B 20 mg lidocaine,group C 2 mg granisetron,group D 2 mg granisetron and 20 mg lidocaine. After 1 min the tourniquet released and a quarter of expected amount of propofol was given. Pain score of injection site was recorded. RESULTS:As group B、C and D,case number of injection nonpain in group A was higher than that of injection pain. There were statistical significance in the difference of case number and degree of injection pain among those groups(P
