Analysis on Influence Factors of Plasma Concentration of Digoxin and Its Rational Use in Our Hospital
- VernacularTitle:地高辛血清浓度影响因素及我院合理应用情况分析
- Author:
Yuguo BAI
;
Guoyi WEI
;
Qiang ZHAO
- Publication Type:Journal Article
- Keywords:
Digoxin;
Serum concentration;
Rational drug use
- From:
China Pharmacy
2005;0(16):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the influence factors of plasma concentration of digoxin(SDC)and application of it in our hospital in order to promote rational use of digoxin. METHODS:445 cases treated with digoxin were collected from our hospital and plasma concentration of digoxin was detected. Multiple stepwise regressions were used to analyze current application of digoxin,relationship between SDC and factors including age,gender(Gen),departments(Dept),drug combination(Drug),serum creatinine concentration(SCR),dose. RESULTS:SDC was relation with age,gender(Gen),departments(Dept),drug combination(Drug),serum creatinine concentration(SCR),dose. CONCLUSION:There are many influence factors of SDC which are different among individual patients. In our survey,16.2% patients taking digoxin occurs adverse reactions. The most common adverse reaction is nausea and poor appetite. We should pay attention to arrhythmia caused by digoxin. The SDC of surgical inpatients were higher than that of medical inpatients(P
