Expression and their clinical significance of p15,p27 in nasopharyngeal carcinoma
- VernacularTitle:p15和p27蛋白在鼻咽癌中的表达及其相关意义
- Author:
Hongsong DONG
;
Deng XIANG
;
Guihua HE
;
Yongtian LU
;
Hong GUAN
;
Yanwei WEN
- Publication Type:Journal Article
- Keywords:
Nasopharyngeal Neoplasms;
CyclinDependent Kinase Inhibitor Proteins;
Immunohistochemistry
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To evaluate the roles of p15,p27 gene protein and expression in nasopharyngeal carcinoma(NPC).METHODS The EnVision immunohistochemical method was used to detect the expression of p15,p27 gene protein in nasopharyngeal carcinoma tissues of 43 NPC cases and non-tumor nasopharyngeal tissues of 21 cases.RESULTS ① The positive expression rates of p15,p27 gene protein were 65%,68% in NPC respectively.There were significant differences between NPC and non-tumor group(P0.05).③The positive expression of p15 gene protein was correlated to the positive expression of p27 gene protein(P
