Relationship between expressions of multidrug resistance associated factors and inhibition of 5-FU to lymph node metastases of colon carcinoma
- VernacularTitle:5-FU对结肠癌转移灶抑制率与耐药相关因子表达关系的实验研究
- Author:
Jianhui ZHAO
;
Bibo TAN
;
Shengchun WU
;
Jie HAN
- Publication Type:Journal Article
- Keywords:
Colonic Neoplasms;
Lymph Node Metastases;
Multidrug Resistance Associated Factors;
Chemosensitivity,5-Fluorouracil
- From:
Chinese Journal of General Surgery
1997;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between expressions of multidurg resistance associated factors and chemosensitivity of 5-fluorouracil(5-FU) in lymph node metastases(LNMs) of colon carcinoma.Methods The chemosensitivity to 5-FU was measured by MTT assay,and the expressions of P-gp,GST-?,p53,survivin,Bcl-2 and Bax were determined immunohistochemically in 48 paired primary tumor(PT) and LNMs of colon carcinoma.Results The inhibition rates of LNMs cells for 5-FU were higher than that of PT(P
