Efficacy of Letrozole in the Treatment of Breast Cancer in Postmenopausal Women:A Systematic Review
- VernacularTitle:来曲唑治疗绝经后妇女乳腺癌疗效的系统评价
- Author:
Kai CHENG
;
Haibo HU
- Publication Type:Journal Article
- Keywords:
Letrozole;
Tamoxifen;
Breast cancer;
Systematic review
- From:
China Pharmacy
2005;0(14):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate efficacy of letrozole in the treatment of breast cancer in postmenopausal women. METHODS:RCTs about letrozole in the treatment of breast cancer in postmenopausal women were collected using Cochrane systematic evaluation method by retrieving from Cochrane Library,PubMed,CBMdisc and CNKI. The quality evaluation of those trials and data extraction were performed and Meta-analysis was conducted by RevMan 5.0 software. RESULTS:6 RCTs involving 6 316 patients were included. In neoadjuvant endocrine therapy,letrozole was more effective than tamoxifen in PFS but there was no statistical significance in difference of total survival rate;in rescue therapy for recurrence and transform,letrozole was more effective than long-term therapy of tamoxifen in OS,PFS and OR;in new neoadjuvant endocrine therapy before operation,letrozole was more effective than tamoxifen in OR. CONCLUSION:The current evidence shows that letrozole is more effective than tamoxifen for breast cancer in postmenopausal women.More high-quality clinical trials are expected for further study.
