Improvement of Content Determination of Rocuronium Bromide by Potentiometric Titration
- VernacularTitle:电位滴定法测定罗库溴铵原料药含量的方法改进
- Author:
Gengshen SONG
;
Jianguo JIANG
;
Kai YAN
;
Wenzhe PANG
- Publication Type:Journal Article
- Keywords:
Rocuronium bromide;
Content determination;
Potentiometric titration methods
- From:
China Pharmacy
2005;0(13):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish a mercury-free perchloric acid potentiometric titration method for the content determination of rocuronium bromide.METHODS:Mettler DG113-SC was used as the composite electrode.The potentiometric titration was performed with glacial acetic acid and acetic anhydride as solvents and perchloric acid(0.1 mol?L-1) as titration.The method was compared with that stated in European Pharmacopeia.RESULTS:The linear range of rocuronium bromide was 0.150 1～0.401 3 g(r=0.999 9) with an average recovery within 99.90%～99.98%.The detection limit was 1.71 mg.There was no difference between results detected by two methods.CONCLUSION:The method is simple,sensitive and accurate for the content determination of rocuronium bromide.
