Determination of the Main Component of Captopril Tablets by Derivative Spectrophotometry
- VernacularTitle:衍生化分光光度法快速测定卡托普利片中主药的含量
- Author:
Zhengping XIONG
;
Kaishun HUANG
;
Lianlian ZHU
;
Zhiqiong CHEN
- Publication Type:Journal Article
- Keywords:
Captopril tablets;
Derivative spectrophotometry;
2,4-dinitrofluorobenzene;
Content determination
- From:
China Pharmacy
2005;0(13):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish derivative spectrophotometry for the determination of the main component of Captopril tablets.METHODS:Under the alkaline condition of sodium hydroxide,2,4-dinitrofluorobenzene was used as derivatization reagent to react with captopril at 40 ℃ in the water bath.Then UV spectrophotometry was adopted to detect the content of captopril with detection wavelength set at 342 nm.RESULTS:The linear range of captopril was 1.0～14.0 ?g?mL-1(r=0.999 9) with an average recovery of 99.61%(RSD=1.27%,n=9).The RSD of intra-day and inter-day both were less than 2%.CONCLUSION:This method is stable,reliable,rapid and simple for the determination of the main components of Captopril tablets.
