Interaction of Baicalin with Berberine for Intestinal Absorption in Rats
- VernacularTitle:黄芩苷与盐酸小檗碱在大鼠小肠吸收的相互作用研究
- Author:
Qingqing DU
;
Zhanguo WANG
;
Fang LIU
;
Xuehua JIANG
- Publication Type:Journal Article
- Keywords:
Baicalin;
Berberine;
Absorption kinetics;
Interaction
- From:
China Pharmacy
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the interaction of baicalin with berberine for intestinal absorption in rats. METHODS: The mode was induced by in situ intestinal perfusion to observe the absorptive kinetics characteristic in rats’ intestine before and after mixing. RESULTS: The absorption rate constant (ka) and absorption rate (A) of baicalin alone were (0.068?0.002)h-1 and (5.92?1.39)% while those of baicalin mixed with berberine were (0.060?0.002)h-1 and (4.27?1.23)% , respectively. ka and A of berberine alone were (0.044?0.003)h-1 and (3.47?0.64)% while those of berberine mixed with baicalin were (0.057?0.006) h-1 and (5.18?0.83)%, respectively. There were significant difference in the absorption rate constant of baicalin after mixing(P
