Study of efficiency enhancement and toxicity reduction effects of scutellaria barbata polysaccharides on cytoxan and its immunological mechanism
- VernacularTitle:SBPS对CTX增效减毒作用及其免疫学机制的研究
- Author:
Gaochen SONG
;
Guiyun WANG
;
Qi DONG
;
Xiudong JIN
- Publication Type:Journal Article
- Keywords:
Liver Neoplasms/drug ther;
Scutellaria Barbata Polysaccharides(SBPS);
Cytoxan;
Efficiency Enhancement and Toxicity Reduction;
Function of Immunity;
IL-2;
TNF-?
- From:
Chinese Journal of General Surgery
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the efficiency enhancement and toxicity reduction effects of scutellaria barbata polysaccharides(SBPS) on mice treated with cytoxan(CTX).Methods Transplanted H22 hepatoma mice were randomly divided into negative control group,CTX group and combined SBPS and CTX group.After 10 d of consecutive drug administration,the tumor inhibitory rate,blood white cell count,phagocytic index and activity of IL-2 were measured.Results SBPS increased the tumor inhibitory rate and reduced the toxicity of cytoxan,and enhanced the function of mononuclear phagocytes and the activity of IL-2 and TNF-?.Conclusions SBPS has efficiency enhancement and toxicity reduction effects on cytoxan,and the mechanism may be by increasing the immunologic function of the organism.
