Adverse Drug Reactions Induced by Fluoroquinolones: Analysis of 308 Cases
- VernacularTitle:308例氟喹诺酮类药致不良反应分析
- Author:
Xiaohong HUANG
;
Xiaojuan ZHANG
;
Guangren LIAO
- Publication Type:Journal Article
- Keywords:
Fluoroquinolones;
Adverse drug reaction;
Analysis
- From:
China Pharmacy
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To investigate the characteristics and regularity of adverse drug reactions (ADR) induced by fluoroquinolones. METHODS: 308 fluoroquinolones-induced ADR cases in 231 literatures were collected from domestic medical journals recorded in CHKD from Jan.1994 to Jun.2009 and analyzed statistically. RESULTS: There was no marked relation between the ADR induced by fluoroquinolones and the gender or age of the patients. 76.62% of ADR cases were mainly caused via intravenous drop infusion. 33.44% of ADR occurred within 2～5 days after medication, leading the first place in term of ADR incidence was levofloxacin (19.81%). ADR mainly appeared as injury of central nervous system (30.43%), followed by lesion of skin and appendants (20.58%). 6 severe ADR induced shock and death. CONCLUSION: Great importance should be attached to monitoring of ADR induced by fluoroquinolones and rational use of drug to guarantee safety and effectiveness of medication.
