Antineoplastic Medicine-induced Adverse Drug Reaction Reported in Our Hospital: Analysis of 162 Cases
- VernacularTitle:我院抗肿瘤药致不良反应162例报告分析
- Author:
Junyan YANG
;
Xiaoli GU
- Publication Type:Journal Article
- Keywords:
Adverse drug reaction;
Antineoplastic medicine;
Report;
Analysis
- From:
China Pharmacy
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To investigate the characteristics and regularity of antineoplastic medicine-induced adverse drug reaction (ADR) occurred in our hospital. METHODS: 162 antineoplastic medicine-induced ADR cases reported in our hospital from 2005 to 2008 were analyzed statistically in respect of patients’age and sex, categories of drugs, route of administration, drug combination,organs and systems involved in ADR and clinical manifestation, etc. RESULTS: Of the total 162 ADR cases, proportion of men was similar to women. 68 cases (41.98%) were old persons aged older than 60. 123 cases(75.93%) were single use of drugs, 39 cases(24.07%) were combined use of drugs. 39.51% of ADR cases were induced by antineoplastic medicine made from plants and took up the first place in terms of incidence of ADR. 36.42% of ADR cases dominantly manifested as lesion of skin and its appendants. CONCLUSION: ADR monitoring of antineoplastic medicine should be strengthened to ensure rational and standardized use of antineoplastic medicine, avoid or reduce the occurrence of severe ADR.
