Dissolution Determination of Erythromycin Ethylsuccinate Granules
- VernacularTitle:琥乙红霉素颗粒溶出度的测定
- Author:
Hongyan SHAO
;
Fengrui WANG
- Publication Type:Journal Article
- Keywords:
Erythromycin ethylsuccinate;
Granules;
Dissolution;
UV spectrophotometry
- From:
China Pharmacy
2007;0(25):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish a method for dissolution determination of Erythromycin ethylsuccinate granules.METHODS:Paddle method was adopted and 0.1 mol?L-1 HCl solution was used as dissolution medium at rotation rate of 50 r?min-1.UV spectrophotometry was used to detect at wavelength of 482 nm.Dissolution rate was calculated.RESULTS:The linear range of erythromycin ethylsuccinate were 4～40 mg?L-1(r=0.999 0,n=5)with an average recovery of 99.19%(RSD=0.56%).Dissolution rate of erythromycin ethylsuccinate was more than 80% within 30 min.CONCLUSION:The method is rapid,simple and accurate for the quality control of Erythromycin ethylsuccinate granules.
