Effect of Irbesartan and Losartan on Pharmacokinetics of Cyclosporin A in Rabbits
- VernacularTitle:厄贝沙坦、氯沙坦对兔体内环孢素A药动学的影响
- Author:
Xiaoqiang QIAN
;
Jiuru ZHANG
;
Jian TANG
;
Xinhui LIU
- Publication Type:Journal Article
- Keywords:
Cyclosporine A;
Irbesartan;
Losartan;
Rabbits;
Pharmacokinetics
- From:
China Pharmacy
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the effect of irbesartan and losartan on pharmacokinetics of cyclosporin A(CsA)in rabbits. METHODS: 12 rabbits were randomly divided into two groups(n=6). In self-controlled study,plasma concentration of CsA in rabbits of two groups before and after treating with combination of irbesartan and losartan were determined and pharmacokinetics parameters were examined. RESULTS: After combination of irbesartan or losartan,the Cmax and AUC0～24 of CsA were significantly increased(P
