Preparation and in Vitro Release of Risperidone Injectable Biodegradable Implants
- VernacularTitle:利培酮生物可降解注射型植入剂的制备及体外释放特性的研究
- Author:
Wei ZHU
;
Hua HUANG
;
Xuefeng SHAN
;
Chao LAI
- Publication Type:Journal Article
- Keywords:
Risperidone;
Injectable biodegradable implants;
Copolymer;
In vitro drug release
- From:
China Pharmacy
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare risperidone injectable biodegradable implants and study its in vitro release. METHODS: Polylactide-co-glycolide copolymer(PLGA)was chosen for carrier and N-Methyl pyrolidone(NMP)as solvent to prepare risperidone injectable biodegradable implants. The percentage of accumulative drug release within 30 days,the change in molecular weight of copolymer and superficial opening diameters of copolymer in function time were observed. RESULTS:Drug release curve of risperidone injectable biodegradable implants for 30 days was stable with small burst. The percentage of accumulative drug release was 89.01% and the percentage of burst accounted for 13.8% at the first 24 hours. The average molecular weight of copolymer decreased to about 10 000 from 43 000 after 30 days and the size of the superficial openings became larger and larger. CONCLUSION:Risperidone injectable biodegradable implants can release continuously and stably in vitro for 30 days.
