Preparation and Quality Control of Anti-Microbicide Contraceptive Gel
- VernacularTitle:抗微生物避孕凝胶剂的制备及质量控制
- Author:
Lilin SHEN
;
Miaomiao LIU
;
Changfeng SHAO
;
Ying ZHANG
;
Jian CHEN
- Publication Type:Journal Article
- Keywords:
Octoxynol;
Policresulen;
Gel;
Quality control
- From:
China Pharmacy
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare anti-microbicide contraceptive gel and establish its quality control method. METHODS: The gel was prepared with octoxynol and policresulen as main ingredients and HPMC as matrix. The content of octoxynol in the gel was determined by HPLC,and the content of policresulen in the gel was determined by titration method. RESULTS:Prepared gel was well-proportioned and of good viscidity and its identification and test were up to the standard. The linear rang of octoxynol was 250～1 500 mg?L-1(r=0.999 6)with an average recovery of 100.84%(RSD=0.74%,n=9). The average labeled amount of policresulen was 106.64%(n=3). CONCLUSION:This preparation is feasible and stable in quality,and the quality control method is simple and accurate.
