Preparation and Quality Evaluation of Lisinopril Polyvinyl Alcohol Particles
- VernacularTitle:赖诺普利聚乙烯醇微粒的制备及其质量评价
- Author:
Junzhu WU
- Publication Type:Journal Article
- Keywords:
Lisinopril;
Polyvinyl alcohol;
Particles;
Spray-drying process;
Preparation;
Quality evaluation
- From:
China Pharmacy
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare lisinopril-loaded polyvinyl alcohol(PVA)particles(LIS-PVA-P)and establish its quality control method. METHODS:LIS-PVA-P was prepared by spray-drying process with PVA as carrier. The preparation was detected in terms of morphology,particle size,span,drug-loading capacity,encapsulation and in vitro dissolution. RESULTS:The preparation assumed sphere with porous surface. The average particle size was 17.29 ?m while drug-loading capacity 31.40%,encapsulation 94.20%,Span was 0.88,90% of the drug loads were released within 30 min. CONCLUSION:The preparation process is simple,good in repeatability and qualified in quality.
