Study on Determination Methods for Dissolution of Oxytetracycline Tablets
- VernacularTitle:土霉素片溶出度测定方法研究
- Author:
Yulian WANG
;
Yonghong ZHU
- Publication Type:Journal Article
- Keywords:
Oxytetracycline tablets;
Dissolution;
UV spectrophotometry
- From:
China Pharmacy
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish a determination method for dissolution of oxytetracycline tablets. METHODS:The content of oxytetracycline was determined by UV spectrophotometry at detection wavelength of 271 nm. Dissolution of oxytetracycline tablets was detected by slurry process using 0.01 mol?L-1 hydrochloric solution as solvent. RESULTS:The linear range of oxytetracycline was 4～32 IU?mL-(1r=0.999 9)with an average recovery of 100.1%(RSD=0.65%). The dissolution in 45 min were all above 75%. CONCLUSION:Established method in this study can be used to determine dissolution of oxytetracycline tablets.
