Content Determination of Pseudoephedrine Hydrochloride and Dextromethorphan Hydrobromide in Pediatric Pseudoephedrine Dextromethorphan Drops Simultaneouly by HPLC
- VernacularTitle:HPLC法同时测定小儿伪麻美芬滴剂中盐酸伪麻黄碱和氢溴酸右美沙芬的含量
- Author:
Enyu CHEN
;
Xiarong SHI
- Publication Type:Journal Article
- Keywords:
HPLC;
Pediatric pseudoephedrine dextrometharphan drops;
Pseudoephedrine hydrochloride;
Dextromethorphan hydrobromide;
Content determination
- From:
China Pharmacy
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish an HPLC method for the content determination of pseudoephedrine hydrochloride and dextromethorphan hydrobromide in pediatric pseudoephedrine dextromethorphan drops. METHODS:The separation was performed nomn .A Tghilee nftl oCw18 rcaotelu wmans wseitth a tm 0o.b6i lme Lp?hmasien -o1f amnedt hthaen oiln-j ewcatitoern- vtroieluthmynla mwainse 1(05 ?60L .∶ 4R3E0S ∶ U10L,TSp:H=Th3e. 0l)ineaat rd reatnegctei own ewrea v7e.3le4n～gt7h3 o.4f ?2g0?9 mL-1 for pseudoephedrine hydrochloride(r=0.999 9,n=5)with an average recovery of 99.1%(RSD=0.76%,n=9)and 2.55～25.5 ?g?mL-1 for dextromethorphan hydrobromide(r=0.999 9,n=5)with an average recovery of 98.0%(RSD=0.87%,n=9). CONCLUSION:The method is accurate and reproducible for quality control of pediatric pseudoephedrine dextrometharphan drops.
