Clinical Observation of PCF and DCF Regimens in the Treatment of Advanced Gastric Cancer
- VernacularTitle:PCF与DCF方案治疗进展期胃癌的临床观察
- Author:
Hongmei ZHANG
;
Ni JIANG
- Publication Type:Journal Article
- Keywords:
Paclitaxel;
Taxotere;
Gastric cancer;
Chemotherapy
- From:
China Pharmacy
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the efficacies and safety of paclitaxel (PTX) versus Taxotere (TXT) and fluorouracil (5-FU) versus cisplatin (DDP) (PCF vs.DCF regimens) in the treatment of advanced gastric cancer (AGC).METHODS:60 cases of AGC were divided into two groups according to different regimens.The patients in group PCF (n=30) received 35～50 mg?m-2 PTX via ivgtt for 3 hours on the 1st,8th,15th day.The patients in group DCF (n=30) received 35 mg?m-2 TXT via ivgtt for 1 hour,on the 1 st,8th,15th day.Both groups were given 750 mg?m-2 5-FU with continuous infusion administration from the 1st to 5th day and 20 mg?m-2 DDP via ivgtt for 2 hours from the 1st to 5th day with treatment course of 28 d.Recent efficacy and safety were evaluated after two cycle of treatment and long-term efficacy were followed up continuously.RESULTS:Overall response rate (ORR) was 50.0% for group PCF and 46.6% for group DCF.Disease control rate (DCR) was 66.6% in group PCF and 63.3% in group DCF.The median survival time (MST) was 10.4 months in group PCF and 9.6 months in group DCF.One-year survival rates were 35.7% for group PCF and 34.4% for group DCF.There was no statistically significance in recent and long-term efficacy between two groups.Grade Ⅲ/Ⅳ toxicities represented as bone marrow depression,nausea,vomiting and alopecia in two groups.Grade Ⅳ neutropenia and the overall incidence of anemia,DCF was significantly higher than the PCF group.CONCLUSION:PCF and DCF regimens have similar response in the treatment of advanced gastric cancer.Drug toxicity of two regimes are different while both of them are tolerable well.
