Study on the Activity of Flavonoids Extracted from Mallotus apelta against Duck Hepatitis B Virus
- VernacularTitle:白背叶黄酮类化合物抗鸭乙型肝炎病毒活性研究
- Author:
Xing XIA
;
Zuowen ZHENG
;
Wei TAN
- Publication Type:Journal Article
- Keywords:
Mallotus apelta;
Flavonoids;
Duck hepatitis B virus;
Activity
- From:
China Pharmacy
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To study the activity of flavonoids WF extracted from Mallotus apelta against duck hepatitis B virus (DHBV).METHODS: One-day-old ducklings were infected with DHBV.7 days later the DHBV-infectious model was established successfully.The model ducklings were administrated with WF of 75 and 150 mg?kg-1 or lamivudine of 50 mg?kg-1 b.i.d.via i.g.gtt for 10 days consecutively.Serums were collected at 5th and 10th day after drug administration and 3th days after drug withdrawal.The level of DHBV-DNA in serum was detected by dot-blotting hybridization test.RESULTS: 75 and 150 mg?kg-1 WF reduced the level of DHBV-DNA significantly(P
