Clinical Efficacy of Nalmefene for Chronic Type Ⅱ Respiratory Failure
- VernacularTitle:纳美芬治疗慢性Ⅱ型呼吸衰竭疗效观察
- Author:
Zhijian DENG
;
Qiang ZHANG
;
Dongmei CAO
;
Jinlan LI
- Publication Type:Journal Article
- Keywords:
Nalmefene;
Respiratory failure;
Treatment
- From:
China Pharmacy
1991;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To study the clinical efficacy of Nalmefene in the treatment of chronic type Ⅱrespiratory failure. METHODS: A total of 40 patients with chronic type Ⅱ respiratory failure were randomly divided into treatment group and the control group: the treatment group received Nalmefene (1.0 mg) plus 5% GS (250 mL) q.d by iv gtt. in addition to the routine treatment, and the control group received 1.875 g Nikethamide plus 5% GS (250 mL) q.d by iv gtt. After 5-day treatment, the clinical symptom, physical signs, adverse drug reactions, lung function testing and blood gas analysis in two groups were evaluated. RESULTS: The overall response rate was 95.0% in the treatment group vs. 60.0% in the control group(P
