Preparation of a Three-pulse Drug Release System of Nimodipine
- VernacularTitle:尼莫地平三次脉冲释药系统的研制
- Author:
Bo TANG
;
Yi WU
;
Meijuan ZOU
;
Xiaoyu LIANG
;
Yanqun ZENG
;
Gang CHENG
- Publication Type:Journal Article
- Keywords:
Nimodipine;
Pulse drug release;
Dry-coating method;
Solid dispersion;
In vitro release
- From:
China Pharmacy
1991;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare a three-pulse drug release system of nimodipine and study its drug release.METHODS:Solid dispersion technique and dry-coating method were respectively applied to prepare immediate-release mini-tablets and Pulsatile mini-tablets with lag-time of 4 h or 8 h.Then those mini-tablets were filled into capsule to obtain a three-pulse drug release system and subjected to in vitro dissolution test.DSC was employed to determine drug status in solid dispersion.RESULTS:Immediate-release mini-tablets were released more than 95% in 30 min.Pulsatile mini-tablets were released less than 10% in 4 h or 8 h of lag-time period.After lag-time period,pulsatile mini-tablets were released completely in 3 h.The whole pulsatile drug release system achieved three times of drug release at 5 min,4 h,8 h,respectively.Nimodipine kept amorphous form and were delivered into carrier evenly.CONCLUSION:A three-pulse drug release system of nimodipine has been prepared successfully.
