Preparation and Quality Control of Hongbei Hydrogel
- VernacularTitle:红倍凝胶的制备及质量控制
- Author:
Jinlong SU
;
Yuan WANG
;
Xiaohong GAO
;
Junmin LI
- Publication Type:Journal Article
- Keywords:
Hongbei hydrogel;
Erythromycin;
Betamethasone;
Preparation;
Quality control
- From:
China Pharmacy
1991;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare Hongbei hydrogel and establish its quality control method.METHODS:Hongbei hydrogel was preparaed using erythomycin and betamethasone as principal agents and carbomer-940 as key base material.The content of erythomycin and betamethasone were determined by UV spectrophotometry at detection wavelength of 483.3 nm and 260 nm,respectively.RESULTS:The preparation assumed colorless smooth semisolid gel.The linear ranges were 9.69～59.43 ?g?mL-1 for erythomycin (r=0.999 3,n=6) and 6.20～20.27 ?g?mL-1 for betamethasone (r=0.999 5,n=6).The average recovery rate were 98.39% (RSD=1.23%) and 98.24% (RSD=0.43%).CONCLUSION:The preparation technology was simple,feasible and practical for quality control.
