Effects of the Shendi Jiangtang Granule on Insulin Sensitivity in Insulin Resistance Accompanied Hypertension Model Rats
- VernacularTitle:参地降糖颗粒对胰岛素抵抗伴高血压模型大鼠胰岛素敏感性的影响
- Author:
Ling WANG
;
Qiugui LI
- Publication Type:Journal Article
- Keywords:
Insulin resistance;
Hypertension;
Tumor necrosis factor (TNF)-?;
Shendi Jiangtang Granule (Granule for reducing glucose);
Fructose-fed rats
- From:
Journal of Traditional Chinese Medicine
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observed the effect of Shendi Jiangtang Granule (Granule for reducing glucos), on insulin sensitivity in insulin resistance accompanied hypertension model rats and its mechanism.Methods Six-week-old male Sprague-Dawley rats were divided into blank group, model group and Chinese medicine group. The blank group were fed with normal rat chow, and the others were fed with fructose-rich chow (FFR). The Chinese medicine group was given Shendi Jiangtang Granule (3.24 g/kg/day). Systolic blood pressure was measured weekly for 6 weeks. Then the euglycemic hyperinsulinemic glucose clamp technique was performed to estimate insulin sensitivity (M value). At the end of the glucose clamp, the soleus and extensor digitorum longus (EDL) muscles were dissected out for determination of the role of tumor necrosis factor-?(TNF-?) by an ELISA assay.Results Treatment with Shendi Jiangtang Granule significantly improved the M value in FFR rats (P
