Cross-talk between nuclear factor-?B and other signaling pathways
- VernacularTitle:核因子?B及其与其它信号通路的交互作用
- Author:
Xian LI
;
Changren ZHOU
;
Shengli NIE
- Publication Type:Journal Article
- Keywords:
NF-kappa B;
Signaling pathway
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Transcription factor NF-?B has attracted attention due to its important role in the regulation of the expression of a number of cellular genes involved in host defense,inflammation/immune responses,cytokine and growth factor regulation,cell survival,proliferation,and also in embryonic development and programmed cell death. In this review,we provide an overview of established TNF-?,TLR/IL-1R,TCR and BCR signaling pathways to NF-?B,the alternative NF-?B pathway,and the regulation of NF-?B transcriptional activity. Furthermore,we discuss on emphasis the cross-talks between NF-?B and other signaling pathways (TGF-?,p53,nuclear receptor family,Ras/MEK/MAPK...),which are very complex and remain to be understood. The activation or inhibition of NF-?B has effect on other signaling pathways. They compose a complex signaling network,in which many regulatory signals integrate systematically and coordinate transcriptional responses to the stimulations. So when NF-?B is used as an important target of drugs in human diseases,the pathological and physiological functions of related signal pathways also should be understood sufficiently.
