The significance of elevated plasmic nitric oxide and endothelin-1 levels in hepatopulmonary syndrome
- VernacularTitle:肝肺综合征患者血浆一氧化氮、内皮素1水平的变化及其意义
- Author:
Xin XU
;
Juan ZHOU
;
Aimin LI
;
Guowei LI
- Publication Type:Journal Article
- Keywords:
Hepatopulmonary Syndrome;
Nitric Oxide;
Endothelin 1
- From:
Chinese Journal of General Surgery
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between plasmic nitric oxide(NO),endothelin-1(ET-1) levels and occurrence of hepatopulmonary syndrome(HPS) in liver cirrhosis with portal hypertension(LCPH) patients.Methods Fifty-two LCPH patients were divided into group Ⅰ(with HPS) and groupⅡ(without HPS).Plasmic NO and ET-1 levels were detected by nitric acid reductase and radioimmunoassay(RIA) respectively.Results Occurrence of HPS in all patients was 11.5%(6/52),and was 30%(3/10) in Child-Pugh class C patients.In group Ⅰ,50%(3/6) patients were in Child-Pugh class C.The comparison showed that plasmic NO levels were significantly higher in group Ⅰ than that in group Ⅱ[(110.40?28.02)?mol/L vs.(79.56?22.12)?mol/L,P0.05).Conclusions Elevated plasmic NO levels is an important characteristic of HPS,and,when combined with Child-Pugh classification,it can be significant for diagnosis of HPS in LCPH patients.
