Sleeve gastrectomy model in DIO rat:establishment and evaluation
- VernacularTitle:胃袖状切除对肥胖大鼠体质量及Ghrelin,GLP-1,PYY_(3-36)水平的影响
- Author:
Zhong OUYANG
;
Yiping WU
- Publication Type:Journal Article
- Keywords:
Gastrectomy/methods;
Food Induction;
Obesity;
Ghrelin;
GLP-1;
PYY3-36;
Rats
- From:
Chinese Journal of General Surgery
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the weight loss mechanism of sleeve gastrectomy.Methods SD rats were fed with high-fat diet to induce obesity,and then the obesity rats were randomly divided into experimental group(underwent SG) and control group(underwent sham surgery).Eight weeks after operation,the body weight,food intake and peripheral blood concentration of Ghrelin,GLP-1,PYY3-36 of rats were checked.Results Compared with controll group,in experimental SG model,food intake was decreased(P 0.05).Conclusions The weight loss of sleeve gastrectomy in DIO rats's decline is lasting and obvious.The postoperative effect of decreased Ghrelin and increased GLP-1,PYY3-36 is the main mechanism for weight loss.
