Effects of Irbesartan on Expression of MMP-2,TIMP-2 and Ⅳ-C in Kidney of Diabetic Rats
- VernacularTitle:厄贝沙坦对糖尿病大鼠肾组织MMP-2、TIMP-2和Ⅳ-C表达的影响
- Author:
Chunpu MAO
;
Xiaoyi LI
;
Hongmei ZHANG
- Publication Type:Journal Article
- Keywords:
Irbesartan;
Diabetic nephropathy;
MMP-2;
TIMP-2;
Ⅳ-C;
Expression
- From:
China Pharmacy
1991;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expression of matrix metallopro teinase-2(MMP-2),tissue inhibitor of metalloproteinase-2(TIMP-2) and collagen Ⅳ(Ⅳ-C) in kidney of diabetic rats and the intervention effect of irbesartan.METHODS:30 male SD rats were randomly divided into three groups:normal control group(NC group),diabetes mellitus group(DM group) and diabetes mellitus+50 mg?kg-1 irbesartan group(DI group).DM and DI group were injected with streptozocin intraperitoneally to reduce diabetic model.After 8 weeks the expression of MMP-2,TIMP-2 and Ⅳ-C in kidney tissure were determined by immunohistochemistry method(SP) and RT-PCR.RESULTS:Compared with NC group,DM group showed the expression of protein and mRNA of MMP-2 significantly reduced while that of TIMP-2 and Ⅳ-C increased(P
