Study on Preparation of Temperature Sensitive Hydrogel of Chitosan/Polyvinyl Alcohol/Sodium Glycerophosphate and Its Characteristics
- VernacularTitle:壳聚糖/聚乙烯醇/甘油磷酸钠温敏性凝胶的制备及特性研究
- Author:
Xudong FU
;
Hong LIU
- Publication Type:Journal Article
- Keywords:
Chitosan;
Polyvinyl alcohol;
Sodium glycerophosphate;
Temperature sensitive hydrogel
- From:
China Pharmacy
1991;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare temperature sensitive hydrogel which is of strength.METHODS:The hygrogel was prepared using CS,PVA and GP as matrix with concentration of CS(A),weight ratio of CS to PVA(B) and pH value(C) as factors and with initial gelatination temperature,strength and dehydration as indexes.The formula was optimized by orthogonal experiment and verified.RESULTS:The optimal formula was as follows:A 20 mg?mL-1,B 1 :1,C 7.2.The prepared hydrogel was fluid at 4 ℃ or room temperature while gelatinized at 37 ℃ within 10 min with strength of about 1.4 kPa.Gelatination time reduced along with the increase of temperature.The pH value had hardly changed during degradation in vitro within 28 d.CONCLUSION:The CS/PVA/GP hydrogel is simple and practical in preparation technique and is temperature sensitive and of strength.
