Anti-aging Effect of Flavonoids of Astragalus complanatus on D-galactose-induced Subacute Aging in Mice
- VernacularTitle:沙苑子黄酮对D-半乳糖所致亚急性衰老模型小鼠的抗衰老作用研究
- Author:
Cuiping WEI
;
Xueliang YU
;
Jikai WU
- Publication Type:Journal Article
- Keywords:
Flavonoids of Astragalus complenatus;
Anti-aging;
Subacute aging model;
Immunity
- From:
China Pharmacy
2007;0(36):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the effect of flavonoids of Astragalus complanatus(FAC) on D-galactose-induced sub-acute aging in mice. METHODS:The subacute aging mice model were established with the use of D-galactose,and the effect of FAC on the associated indexes in model mice such as enzymes,immune organ indexes,hypoxia tolerance time,swimming time under hypoxic condition etc were recorded. RESULTS:FAC treatment significantly up-regulated the activity of SOD,down-regulated MDA content,markedly increased the spleen index and thymus index,prolonged the surviving and swimming time markedly under anoxia condition. CONCLUSION:FAC has anti-aging effect and it can enhance mice's abil-ity against hypoxia and fatigue,which is probably associated to the enhancement of the nonspecific immunity in mice.
